Verbal recall and recognition in twins discordant for schizophrenia

Volumes of brain structures in twins discordant for schizophrenia.

BACKGROUND The study was designed to examine the relative contributions of genetic and nongenetic factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder. METHODS The brains of 15 monozygotic and 14 same-sex dizygotic twins discordant for schizophrenia (patients) and 29 healthy twins pair-wise matched for zygosity, sex, age, and birth order were...

Brain dopamine d1 receptors in twins discordant for schizophrenia.

OBJECTIVE It has been suggested that deficits in higher-order cognitive functions serve as intermediate phenotypic indicators of genetic vulnerability to schizophrenia. The dopamine hypothesis of schizophrenia postulates that insufficiency of dopamine transmission in the prefrontal cortex contributes to the cognitive deficits observed in patients with the disease, and there is robust empirical ...

Language activation in monozygotic twins discordant for schizophrenia.

BACKGROUND In previous functional magnetic resonance imaging (fMRI) studies, participants with schizophrenia showed decreased language lateralisation, resulting from increased activation of the right hemisphere compared with controls. AIM To determine whether decreased lateralisation and increased right cerebral language activation constitute genetic predispositions for schizophrenia. METHO...

Etiological Implications of Studies of Identical Twins Discordant for Schizophrenia

I should like to share with you our experiences in studying identical twins discordant for schizophrenia, for I believe that these investigations have taught us a number of lessons about the problems inherent in research on schizophrenia. I also feel fairly confident that they have brought us closer to the long-hoped-for day when some answers to the schizophrenia conundrum will be forthcoming. ...

Early characteristics of monozygotic twins discordant for schizophrenia.